Acid—CoA ligase (GDP-forming)

acid-CoA ligase (GDP-forming)
Identifiers
EC number 6.2.1.10
CAS number 37318-59-5
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / EGO

In enzymology, an acid-CoA ligase (GDP-forming) (EC 6.2.1.10) is an enzyme that catalyzes the chemical reaction

GTP + an acid + CoA \rightleftharpoons GDP + phosphate + acyl-CoA

The 3 substrates of this enzyme are GTP, acid, and CoA, whereas its 3 products are GDP, phosphate, and acyl-CoA.

This enzyme belongs to the family of ligases, specifically those forming carbon-sulfur bonds as acid-thiol ligases. The systematic name of this enzyme class is acid:CoA ligase (GDP-forming). Other names in common use include acyl-CoA synthetase (GDP-forming), and acyl coenzyme A synthetase (guanosine diphosphate forming).

References